More Evidence From an Israeli Study that Breast Cancer Risk is Not Increased in Noncarriers of Family-Specific BRCA1/2 Mutations
We recently mentioned a new study looking at the risk of breast cancer in women testing negative for a known BRCA1 or BRCA2 mutation in their family. Another relevant study was just published. Dr. Eitan Friedman and colleagues have looked at breast cancer rates in non-carriers of familial BRCA1/BRCA2 mutations in Jewish families identified at the Chaim Sheba Medical Center. Their study suggests...
Read MoreNew Answer in Our Q&A Section to a Reader Submitted Question
We’ve posted an answer to a reader-submitted question in the BRCAscoop Q&A Section. A reader whose father apparently has deleterious mutations in both the BRCA1 and BRCA2 genes asked whether it is possible that he/she could have avoided inheriting at least one of those mutations. For the answer, check out our Q&A section or send us your own question below! _____ Ask Your Own...
Read MoreBreast Cancer Risk in Women Testing Negative for a Familial BRCA1 or BRCA2 Mutation
If you have a BRCA1 or BRCA2 mutation, you presumably heard in your genetic counseling session that other members of your family have an opportunity to be tested for the mutation that you have, and that this testing can help to clarify their risk for breast, ovarian and other cancers. Women found to have the family-specific BRCA mutation can pursue more aggressive screening and preventative...
Read MoreBRCA1 Mutations Are Relatively Common in Women with Ovarian Cancer in Colombia
Previous studies of Hereditary Breast and Ovarian Cancer in Colombia have revealed the following: Certain BRCA founder mutations are present in about 4 percent of unselected individuals with breast cancer in the Bogota, Colombia area Several founder mutations have been identified in the region, including 2 in BRCA1 (A1708E, 3450del4) and 3 in BRCA2 (3034delACAA, 6076delGTTA, 6503delTT) Despite...
Read MoreA Vero Beach Physician Reducing Her Own Hereditary Breast and Ovarian Cancer Risk
A new story at TCPalm.com focuses on Dr. Nancy Baker – a Vero Beach, Florida family physician with Hereditary Breast and Ovarian Cancer susceptibility – and her decision to pursue bilateral prophylactic mastectomy and, several years later, bilateral prophylactic removal of her ovaries and fallopian...
Read MoreBasic Science Watch: New Paper Yields Important Progress In Deciphering How Normal BRCA1 Prevents Cancer
If you have a BRCA1 mutation and have ever wondered just how a normal BRCA1 gene prevents breast cancer, the results of a new study bring the scientific community a bit closer to answering this question. A team led by Drs. Thomas Ludwig and Richard Baer (both of Columbia University) recently reported the results of experiments designed to evaluate 2 possible mechanisms behind BRCA1′s...
Read MoreWhen Was Your Last Mammogram?
When clinical researchers gauge to what extent women with BRCA1 and BRCA2 mutations are adhering to appropriate breast cancer screening recommendations, they often use self-reported information about mammogram frequency and dates. A new study by Dr. Michel Dorval (Université Laval, Quebec, Canada) and colleagues looked at whether self-reported mammography use at their institution was actually...
Read MoreBRCA1 and BRCA2 Mutations in Greek Breast Cancer Patients
There have been a moderate number of previous studies focusing on the role of BRCA1 and BRCA2 mutations in Hereditary Breast and Ovarian Cancer syndrome in Greece. You can see some of the key findings and references on our BRCA1 and BRCA2 in Greece page. Previous studies have revealed a few key things. Among them: 4 specific mutations in BRCA1 have been described to play a key role in...
Read MoreBRCA1 and BRCA2 Mutations Are Relatively Frequent in Nigerian Breast Cancer Patients
In situations where genetic medicine has the potential to provide health benefits, they’ve largely been confined to the developed world. Hereditary Breast and Ovarian Cancer syndrome is an excellent example. Women with a strong personal and/or family history of breast and ovarian cancer have access to technology – genetic testing for mutations in the BRCA1 and BRCA2 genes –...
Read MoreThe Core of What We Do For You Every Month
There has been an explosion of basic science, translational, and clinical research focused on the BRCA1 and BRCA2 genes. If you or someone you care about has elevated cancer risk due to a mutation in one of these genes, the research explosion is a great thing as it is precisely this kind of work that has identified approaches for cancer prevention and treatment that are relevant to you today. ...
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