PARP Inhibitor Abstracts at this Week’s ASCO Meeting
This is the first in a weekly series of posts focusing on PARP inhibitors. Look for them every Monday on the BRCAscoop Blog. With the ASCO (American Society of Clinical Oncology) Meeting approaching, we’re going to kickoff the weekly post series focused on PARP inhibitors with links to PARP inhibitor-related abstracts at the upcoming meeting. In general, we try to focus on...
Read MoreBRCA1 and Prostate Cancer Risk
Although the most significant impact of the Hereditary Breast and Ovarian Cancer genes BRCA1 and BRCA2 is on breast and ovarian cancer risk in women, that – of course – is not the whole story. Risks for some other cancer types are elevated too, including breast and prostate cancer in men. Not surprisingly given the impact that risk of breast and ovarian cancer has on women with...
Read MoreMore Patients with Mutations in Both BRCA1 and BRCA2
Last year, we discussed a report of two patients with deleterious mutations in both the BRCA1 and BRCA2 genes. Recently, two new case reports were published pointing out the occurrence of mutations in both genes in individuals from both Germany and South Africa. Although relatively unusual, these examples serve as reminders that: 1. It happens. Occasionally, individuals are identified with a...
Read MoreNew on the BRCAscoop Blog – Blog Post Series
This is just a heads up that we are going to take several of the topics that many of you out there seem most interested in and turn them into regular recurring series that will run for at least the next few weeks here on the BRCAscoop Blog. You can look out for posts in the following areas by day: Mondays – PARP Inhibitors Tuesdays – Controversies in Hereditary Breast and Ovarian...
Read MoreBRCA1 and BRCA2 Large Rearrangements are Important in Hereditary Breast and Ovarian Cancer Risk
Large rearrangements (i.e., deletions and duplications of one or more exons or the entire gene) play an important role in the spectrum of mutations in BRCA1 and BRCA2 that confer Hereditary Breast and Ovarian Cancer Risk. Here’s part 1 of a new series of posts about the impact of BRCA1 and BRCA2 large rearrangements at Cancer And Your...
Read MoreA New Study of BRCA1 and BRCA2 in Breast Cancer Patients from Thailand and Pakistan
There’s a growing amount of information about the extent to which inherited BRCA1 and BRCA2 mutations play a role in breast and ovarian cancer risk in Asia. A new paper adds to the available information for patients in Thailand and Pakistan. In this international study, Dr. Fabienne Lesueur and colleagues studied a total of 207 breast cancer patients from Pakistan and Thailand. The 77...
Read MoreThe 3 Common Ashkenazi Jewish Mutations in BRCA1/2: A Large Study of Cancer Risk and Risk Reduction
Many people are unaware that the frequency of BRCA1 and BRCA2 mutations in Ashkenazi Jews is ~1 in 40. This relatively high rate significantly impacts the Jewish community and is due to 3 common founder mutations: BRCA1 c.68_69delAG (often referred to as 185delAG or 187delAG) BRCA1 c.5266dupC (often referred to as 5382insC or 5385insC) BRCA2 c.5946delT (often referred to as 6174delT) Because...
Read MoreA Hereditary Breast Cancer Patient Jumps into the Planned Parenthood Debate
Noticed today: a hereditary breast cancer patient jumped into the Planned Parenthood debate with a powerful piece in the Huffington Post.
Read MoreNew Knowledge About BRCA1 and BRCA2 Impact in Hereditary Breast and Ovarian Cancer in Morocco
Our current knowledge of the impact of “germline” BRCA1 and BRCA2 mutations on Hereditary Breast and Ovarian Cancer in Morocco and individuals of Moroccan descent is pretty sparse. However, a new paper just published online, in the journal Gynecologic Oncology, from a group led by Dr. Amal Tazzite of the Medical School of Casablanca is an important contribution. Due to the limited...
Read MoreThe BRCAscoop 2011 Hereditary Breast and Ovarian Cancer Research Report – Get Your Copy Now!
Are you a BRCA1 or BRCA2 mutation carrier? Or perhaps you know one – maybe a friend or family member? If so, you or someone you know may be interested in the following information. We are pleased to announce the widespread availability of The BRCAscoop 2011 Hereditary Breast and Ovarian Cancer Research Report for immediate download. It’s a wonderful way for BRCA1 and BRCA2...
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